Trane XV80 air handlers.
These really caused me pain at a previous house putting several volts of noise onto the powerline whenever the fan was running. The noise was such that it would interrupt X10 signals as you would expect, but it also would put many modules into a mode where they would just randomly turn on, or would turn on when the next signal was received regardless of the address of it. Several nights I had to jump out of bed and hit the button on our bedroom overhead lights which had just popped on before it awoke my wife… The solution was to rewire the air handlers in the attic! Instead of a direct connection to their power circuit a regular 15 amp electrical outlet was installed and a heavy duty plug installed on the wires to the air handler. This allowed me to plug the entire air handler into a 15 amp X10 filter solving the problem completely. Since it was only the blower on that circuit it was no problem to do this as we were not dealing with high amperage heat strips or the AC compressor.
any of these things may cause trouble for other powerline protocols as well. Different things may cause problems for insteon or UPB but similar things will and do cause problems for them too.