XTension requires at least OSX 10.4 on PPC or Intel (universal binary) but 10.5 or later is recommended. (As of this writing XTension will still run on 10.3.9 but this is now an unsupported installation and the support will be going away for real by the end of 2010.) It will also run fine on 10.6 but the USB devices seem to only work when running the 32bit kernel at the moment.
NOTE: a bug in 10.6 detailed here
http://db.tidbits.com/article/10643 may cause problems for XTension and other scriptable OSX apps under 10.6. After reading that I cannot recommend that you update to 10.6 until that is fixed by Apple.